31. The introduction of Albert Lehninger discovered in 1948 that mitochondria are the site of oxidative phosphorylation in eukaryotes. 32. They share the initial pathway of glycolysis but aerobic metabolism continues with the Krebs cycle and oxidative phosphorylation . 33. But the speed at which ATP is produced in this manner is about 100 times that of oxidative phosphorylation . 34. The amount of energy released by oxidative phosphorylation is high, compared with the amount produced by anaerobic fermentation. 35. In mitochondria, it is found in cytochrome c oxidase, which is the last protein in oxidative phosphorylation . 36. This alternative route for protons uncouples oxidative phosphorylation and the energy in the PMF is instead released as heat. 37. This metabolic alteration is described by the up-regulation of oxidative phosphorylation -called the inverse Warburg Effect. 38. ETQ-QO links the oxidation of fatty acids and some amino acids to oxidative phosphorylation in the mitochondria. 39. Its functions is to separate the oxidative phosphorylation from synthesis of ATP as energy which is anticipated as heat. 40. In oxidative phosphorylation the energy for ATP formation is derived from an plasma membrane ) via the electron transport chain.
