Debate continues that it is " . . . unclear whether LDL particle size measurements add value to measurement of LDL-particle concentration ", though outcomes have always tracked LDL-particle, not LDL-C, concentrations.
32.
Though mechanisms only partially understood, high levels of ApoB, especially associated with the higher LDL particle concentrations, are the primary driver of NMR methods allow measurement distinctions between the many different ApoB particles.
33.
Since LDL particle concentrations are a driver of cardiovascular disease like phase III clinical trials, are now underway to describe the effect of PCSK9 inhibition on cardiovascular disease, and the safety and efficacy profile of the drugs.
34.
Multiple additional measures, including LDL particle concentrations, small LDL particle concentrations, VLDL concentrations, estimations of insulin resistance and standard cholesterol lipid measurements ( for comparison of the plasma data with the estimation methods discussed above ) are routinely provided in clinical testing.
35.
A review published in 2015 concluded that these agents, when used in patients with high LDL-particle concentrations ( thus at greatly elevated risk for cardiovascular disease ) seem to be safe and effective at reducing all-cause mortality, cardiovascular mortality, and heart attacks.
36.
Multiple additional measures, including LDL particle concentrations, small LDL particle concentrations, VLDL concentrations, estimations of insulin resistance and standard cholesterol lipid measurements ( for comparison of the plasma data with the estimation methods discussed above ) are routinely provided in clinical testing.
37.
With continued research, decreasing cost, greater availability and wider acceptance of other " lipoprotein subclass analysis " assay methods, including NMR spectroscopy, research studies have continued to show a stronger correlation between human clinically obvious cardiovascular events and quantitatively measured particle concentrations.
38.
Since higher blood LDL, especially higher LDL particle concentrations and smaller LDL particle size, contribute to this process more than the cholesterol content of the HDL particles, LDL particles are often termed " bad cholesterol " because they have been linked to atheroma formation.
39.
The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U . S . Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
40.
Multiple other measures, including particle sizes, small LDL particle concentrations, large total and HDL particle concentrations, along with estimations of insulin resistance pattern and standard cholesterol lipid measurements ( for comparison of the plasma data with the estimation methods discussed above ) are also routinely provided.
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