31. Research to develop new pepsin -targeted therapeutic and diagnostic tools for gastric reflux is ongoing. 32. Soon after, Schwann discovered pepsin was the substance responsible for albuminous digestion in the stomach. 33. Pepsin is commonly used in the preparation of F ( ab') 2 fragments from antibodies.34. Another partially activated pepsinogen completes the activation by removing the peptide, turning the pepsinogen into pepsin . 35. Discovered in 1836, pepsin was one of the first enzymes to be classified as an exoenzyme. 36. Naturally occurring digestive agents such as pepsin and hydrochloric acid are typically used to accomplish artificial digestion. 37. A prime example of this is pepsin , which is secreted in the stomach by chief cells. 38. Gr�tzner is credited with introducing a colorimetric method for determining the quantity of pepsin in a solution. 39. Finding the answer to this clue means researching terms such as metabolism, nerve cells and pepsin . 40. Pepsin also undergoes feedback inhibition; a product of protein digestion slows down the reaction by inhibiting pepsin.