Assuming linear pharmacodynamics with elimination rate constant " K ", one can show that AUC is proportional to the " total amount of drug absorbed by the body ".
32.
In individuals with ADHD, there is significant evidence that phenethylamine ( PEA ) & ndash; an endogenous amphetamine homologue with analogous dopaminergic pharmacodynamics & ndash; metabolism is reduced compared to healthy individuals.
33.
They differ in both pharmacokinetics ( absorption factor, half-life, volume of distribution, clearance ) and pharmacodynamics ( for example the capacity of mineralocorticoid activity : retention of sodium ( Na + ) and albumin.
34.
Although little is known about the short-and long-term pharmacodynamics and bioavailability of circulating metal degradation products in vivo, there have been many reports of immunologic type responses temporally associated with implantation of metal components.
35.
Pharmacokinetics describes the effect of the body on the chemical ( e . g . half-life and volume of distribution ), and pharmacodynamics describes the chemical's effect on the body ( desired or toxic ).
36.
Pihoker C, Kearns GL, French D, Bowers CY . Pharmacokinetics and Pharmacodynamics of Growth Hormone Releasing Peptide-2 : A Phase I Study in Children J Clin Endocrinol Metab 1998; 83 : 1168-72.
37.
The pharmacokinetics and pharmacodynamics ( S-COMT activity ) of opicapone was similar in a study comparing healthy Japanese and matched white subjects following a 10 day once daily treatment with 5, 25 and 50 mg of opicapone.
38.
Conversion between extended-release and immediate-release ( or " regular " ) morphine is easier than conversion to or from an equianalgesic dose of another opioid with different half-life, with less risk of altered pharmacodynamics.
39.
He joined Schering AG in 1961, and was director of the departments for biological chemistry ( 1962 1970 ), animal experiments in pharmacodynamics and chemotherapy ( 1970 1980 ), and pharmaceutical chemistry and pharmacodynamics ( from 1980 ).
40.
He joined Schering AG in 1961, and was director of the departments for biological chemistry ( 1962 1970 ), animal experiments in pharmacodynamics and chemotherapy ( 1970 1980 ), and pharmaceutical chemistry and pharmacodynamics ( from 1980 ).
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