In this way, the SIP technology is designed to optimize peptide synthesis, increase biological half-life, improve peptide stability and inhibit enzymatic degradation without altering pharmacological activity or profile of action.
32.
Among the class of compounds characterized from " S . visco " leaves, the triterpenoid lupeol, ?-amyrin and ?-amyrin may be mainly responsible for the pharmacological activities.
33.
Preliminary " in vitro " investigations indicate that the " in vivo " pharmacological activity likely undergoes rapid " chemo-inactivation " via cysteine adduct formation followed by slow biodegradation via ester hydrolysis.
34.
The wide range of pharmacological activities of this plant might support the efficacy of extract preparation of " Quercus infectoria " that are widely used in Malaysia for treating many kinds of health problems since many decades ago.
35.
However, six of them, including kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin, have been determined to be responsible for about 96 % of the plant's pharmacological activity . ), pipermethystine.
36.
While detecting trace amounts may be an entirely appropriate approach for performance altering substances which have no approved veterinary use, it is not considered appropriate for therapeutic medications which may be present in trace amounts having negligible or no pharmacological activity.
37.
"' Rogletimide "'is a drug related in chemical structure to the sedative glutethimide, but instead having pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide, but with no significant sedative effect.
38.
"From a scientific perspective it's very interesting, because natural materials haven't been extensively evaluated for pharmacological activity, " said John Samuel, an assistant professor in the pharmacy faculty who helped purify the protein.
39.
These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although " in vitro " binding studies show DFMDA to have a ethylidenedioxy and isopropylidenedioxy analogues.
40.
In a 2010 survey of 1000 plants, 356 had clinical trials published evaluating their " pharmacological activities and therapeutic applications " while 12 % of the plants, although available in the Western market, had " no substantial studies " of their properties.
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