31. TPA-- tissue plasminogen activator or Activase-- was the first widely used clot dissolver but is the hardest to give. 32. Urokinase is encoded in humans by the " PLAU " gene, which stands for " plasminogen activator , urokinase ". 33. One of the most exciting is called tissue plasminogen activator ( TPA ), also called a " clot-buster ." 34. TPA, for tissue plasminogen activator , can re-establish blood flow to the brain and cut the risk of stroke damage. 35. Splice variant i and conserved domain CCP are > 99 % structurally similar to t-plasminogen activator ( PLAT ). 36. Tissue plasminogen activator is a protein encoded by the " PLAT " gene, which is located on chromosome 8. 37. The first animal to synthesise transgenic proteins in their milk were mice, engineered to produce human tissue plasminogen activator . 38. PGRMC1 shares key structural motifs with PAIR-BP1 ( plasminogen activator inhibitor RNA-binding protein-1 ) . which regulates cholesterol synthesis. 39. Treatment with tissue plasminogen activator , or TPA, must start within three hours of the onset of stroke symptoms, Morgenstern said. 40. Alteplase and similar drugs such as TPA ( tissue plasminogen activator ) are already a mainstay of heart attack treatment.
