The processing of the polyprotein occurs in a highly regulated manner, with cleavage at the P2 / 3 junction influencing RNA template use during genome replication.
32.
As opposed to alpha viruses the capsid does not undergo autoprotolysis, rather is it cut off from the rest of the polyprotein by the signal-peptidase.
33.
Blood clotting ( such as thrombin ) and viral polyprotein processing ( such as TEV protease ) requires this level of specificity in order to achieve precise cleavage events.
34.
Despite occupying 7.3 % of the polyprotein it is responsible for 26.2 % to 33.3 % of the variation found between the Iflaviridae.
35.
The HIV nucleocapsid protein ( NC ) is a 7 kDa zinc finger protein in the Gag polyprotein and which, after viral maturation, forms the viral nucleocapsid.
36.
The polyprotein coat of CfMV is made up of two proteins, encoded by overlapping open reading frames ( 2a and 2b ) which are transcribed through a ribosomal frameshift mechanism.
37.
This polyprotein is proteolytically processed by viral proteases ( NIa, HC-Pro and P1 ) and undergoes co-and posttranslational cleavage to yield several multi-functional proteins.
38.
The " env " gene is translated into a single precursor polyprotein that is cleaved by a host protease into two proteins, the surface glycoprotein and the transmembrane glycoprotein.
39.
As a result, the HIV-1 ribosomal frameshift signal is highly regulated, as it modulates the expression levels of the Gag protein relative to the Gag-Pol polyprotein.
40.
Cyclophilin A is also known to be recruited by the Gag polyprotein during HIV-1 virus infection, and its incorporation into new virus particles is essential for HIV-1 infectivity.
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