31. This property of the NMDA receptor explains many aspects of long-term potentiation ( LTP ) and synaptic plasticity. 32. Anaesthetic efficacy is achieved by allosteric potentiation of the GABA A chloride channel to produce'fast'synaptic inhibition. 33. Nevertheless, there can also appear important drawbacks such as antagonizing mechanisms of action or potentiation of deleterious secondary effects. 34. Notably, AMPA and NMDA receptors are key molecules in mechanisms of long and short-term potentiation between neurons. 35. SGK has been to shown to facilitate the expression of long-term potentiation in hippocampal neurons and neuronal plasticity. 36. This includes the reduction of post-tetanic potentiation at synapses which prevents cortical seizure foci from detonating adjacent cortical areas. 37. These lower levels seem to be linked to the rescue of stress-induced attenuation of CA1 long-term potentiation . 38. The long form Homer1c plays a role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation . 39. It usually lasts in the range of several minutes ( shorter potentiations are usually referred to as'augmentations'). 40. Unlike the VTA, a single dose of cocaine induces no change in potentiation in the excitatory synapses of the NAc.
