It activates thyroid hormone by converting the prohormone thyroxine ( T 4 ) by outer ring deiodination ( ORD ) to bioactive thyroid, and may contribute significantly to the relative increase in thyroidal T 3 production in patients with Graves'disease and thyroid adenomas.
32.
It is synthesized from 11?-hydroxyandrostenedione and, to a lesser extent, 11-ketoandrostenedione ( adrenosterone ) . 11-Ketoandrostenedione has notably been sold online as an androgen prohormone, usually under the name 11-oxoandrostenedione ( 11-OXO ).
33.
It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine ( T 4 ) and the bioactive hormone 3, 3', 5'- triiodothyronine ( RT 3 ) and 3, 3'- diiodothyronine ( T 2 ), respectively.
34.
On the other hand, said Dr . Robert S . Jackson, the lead author on the study, she had " astronomical amounts " of proinsulin, a precursor molecule that is converted to insulin by an enzyme called prohormone convertase 1 ( or PC1 ).
35.
Although CMA was sold as a " prohormone " or " prosteroid " of chloromethyltestosterone ( CMT; also known more commonly as methylclostebol ), it is likely that the conversion is far from complete and that much of the activity of the drug may be attributable to its unchanged form.
36.
BNP is synthesized as a 134-amino acid preprohormone ( preproBNP ), encoded by the human gene NPPB . Removal of the 25-residue N-terminal signal peptide generates the prohormone, proBNP, which is stored intracellularly as an O-linked glycoprotein; proBNP is subsequently cleaved between arginine-102 and serine-103 by a specific convertase ( probably furin or corin ) into NT-proBNP and the biologically active 32-amino acid polypeptide BNP-32, which are secreted into the blood in equimolar amounts.
37.
"' 7-Ketodehydroepiandrosterone "'( "'7-keto-DHEA "'), also known as "'7-oxoprasterone "', is a steroid produced by metabolism of the prohormone dehydroepiandrosterone ( DHEA ) . 7-Keto-DHEA is not directly converted to testosterone or estrogen, and has thus been investigated as a potentially more useful relative of DHEA . It is often used as the acetate ester prodrug "'7-keto-DHEA acetate " '.
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