31. Among these are such potent chemicals as tumor-necrosis factor and prostaglandins . 32. Antipyretics cause the hypothalamus to override a prostaglandin -induced increase in temperature. 33. The arachidonate is then acted upon by the cyclooxygenase component of prostaglandin synthase. 34. A given prostaglandin may have different and even opposite effects in different tissues. 35. This is probably caused by the release of prostaglandins . 36. It has also been shown that flunoxaprofen inhibits leukotriene rather than prostaglandin synthesis. 37. The structure of lactoperoxidase consists mainly of prostaglandin H synthase ( PGHS ). 38. He also published seminal papers of the implication of prostaglandins in heart disease. 39. Its derivatives are prostaglandins -physiologically active lipid substances. 40. Prostaglandins are often seen as " bad " because they cause pain.