"' Quantitative traits "'are phenotypes ( characteristics ) that vary in degree and can be attributed to polygenic effects, i . e ., the product of two or more genes, and their environment.
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The goal of elucidating pathophysiology has also led to increased interest in the association between risk-SNPs and the gene expression of nearby genes, the so-called expression quantitative trait loci ( eQTL ) studies.
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To drastically change a quantitative trait controlled by many genes ( a polygenic trait ) is likely to require mutations in more than one gene or changes in regulation of more than one gene.
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Families of recombinant inbred strains numbering from 25 to 5000 are often used to map the locations of DNA sequence differences ( quantitative trait loci ) that contributed to differences in phenotype in model organisms.
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Recent studies using genome-wide scan revealed two quantitative trait loci on chromosome 9 and chromosome 18 may be responsible for genetic predisposition or susceptibility to infection of " T . trichiura " by some individuals.
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Although the potential of DH populations in quantitative genetics has been understood for some time, it was the advent of molecular marker maps that provided the impetus for their use in identifying loci controlling quantitative traits.
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Whereas medical genetics has historically tended to dichotomize monogenic traits, governed by simple, Mendelian inheritance, and quantitative traits, with cumulative, multifactorial causes, increasing evidence suggests that human diseases exist on a continuous spectrum between the two.
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Ongoing research includes analyzing the genetic architecture of quantitative disease resistance and dissecting quantitative trait loci to identify mechanisms and genes that impair pathogen development, with a particular interest in multiple disease resistance and mycotoxin resistance.
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In 1923, Sax first reported association of a simply inherited genetic marker with a quantitative trait in plants when he observed segregation of seed size associated with segregation for a seed coat color marker in beans ( " Phaseolus vulgaris"
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Linkage analysis and genetic association studies ( typically quantitative trait locus association studies, which use microarrays to look at single nucleotide polymorphisms of multiple genes at once ) have been used to identify candidate genes that may be implicated in dyslexia.
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