""'Pseudomonas aeruginosa " "'is a common multidrug resistant pathogen recognised for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious illnesses especially hospital-acquired infections such as ventilator-associated pneumonia and various sepsis syndromes.
32.
The chemical mode of action of taurolidine via its reactive methylol groups confers greater potency in vivo than indicated by in vitro minimum inhibitory concentration ( MIC ) values, and also appears to preclude susceptibility to resistance mechanisms.
33.
Another resistance mechanism employed by both " C . albicans " and " C . glabrata " is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters.
34.
Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA . Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains.
35.
"We have to understand those resistance mechanisms so we can defeat the cancer's natural instinct to survive, " says Dr . Bhoomi Mehrotra of Long Island Jewish Medical Center . _ Spreading cancer may have too many targets for targeted therapy.
36.
Their atomic investigation of mutant KIT receptor which emphasized on the EAL region provided a better insight into the understanding of the sunitinib resistance mechanism of the KIT receptor and could help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy.
37.
The mission of IPP is the study of stress factors in plants, to identify resistance mechanisms and methods of defence against biotic and abiotic stress protection in order to improve the quality and quantity of agricultural food production in a sustainable and environmentally friendly manner.
38.
The majority are sensitive to most antibiotics designed for this bacteria class, but this is complicated by their inducible resistance mechanisms, particularly lactamase, which means that they quickly become resistant to standard antibiotics during treatment, requiring a change in antibiotic to avoid worsening of the sepsis.
39.
Conversely, increased deoxycytidine kinase activity is associated with increased activation of these agents to cytotoxic nucleoside triphosphate derivatives . dCK is clinically important because of its relationship to drug resistance and sensitivity . and so more combination therapies are currently been studied to reduce biological resistance mechanisms and drug tolerance in patients.
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