This approach ( e . g ., ViewRNA assays ) can be used to visualize up to four targets in one assay, and it uses patented probe design and bDNA signal amplification to generate sensitive and specific signals.
32.
The triode, despite being the oldest signal amplification device, also can ( depending on the device in question ) have a more linear no-feedback transfer characteristic than more advanced devices such as beam tetrodes and pentodes.
33.
A target-specific probe set containing 20 oligonucleotide pairs hybridizes to the target RNA . An oligo pair hybridization event is essential for support of the signal amplification structure, which is assembled by a series of sequential hybridization steps.
34.
The limited means for signal amplification required that the " Telefon H�rmond?" employ strong-voiced " stentors " to speak loudly into double-cased telephones, so that they could be heard throughout the system by listeners that used headphones.
35.
Although the concept of home audio entertainment was attractive to potential U . S . subscribers, the lack of signal amplification and other technical limitations, such as the need to maintain a telephone line infrastructure, and having to listen over headphones, made the technology unprofitable.
36.
Taking a more sophisticated approach, receptor reserve is an integrative measure of the response-inducing capacity of an agonist ( in some receptor models it is termed intrinsic efficacy or intrinsic activity ) and of the signal amplification capacity of the corresponding receptor ( and its downstream signaling pathways ).
37.
Other advanced techniques, such as nonradioactive " in situ " hybridization, can be combined with immunochemistry to identify specific DNA or RNA molecules with fluorescent probes or tags that can be used for immunofluorescence and enzyme-linked fluorescence amplification ( especially alkaline phosphatase and tyramide signal amplification ).
38.
The last of these appeared in two distinct variants with different areas of application : the screen-grid valve proper, which was used for medium-frequency, small signal amplification, and the beam tetrode which appeared later, and was used for audio or radio-frequency power amplification.
39.
Since C3 convertases cleave C3 to produce C3b which can then form an additional C3 convertase through the alternative pathway, this is a potential mechanism of signal amplification in the complement cascade resulting in the deposition of large numbers of C3b molecules on the surface of activating particles, enabling opsonisation and acute local inflammation.
40.
In 2007 he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high density micro-arrays for genetic analysis, and authoring the standard undergraduate biochemistry textbook, " Jeremy Berg, John L . Tymoczko and Gregory J . Gatto, Jr.
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