Terminology to describe viruses with different hosts has not been approved by the International Committee on Taxonomy of Viruses ( ICTV ); however, Pegivirus A viruses have been called HPgV for human pegivirus, SPgV for new world simian pegiviruses, and SPgVcpz for chimpanzee simian virus.
32.
In the glare of public and government attention over the experiment, the foundation agreed to try and identify a " cleaner " baboon, one freer of simian viruses than those they already provided to the Pittsburgh researchers, said Tom Butler, chief of laboratory animal medicine at the foundation.
33.
Simian virus 5 and type II human parainfluenza virus express a protein, named " V ", which acts as a substrate receptor and bridges an interaction between DDB1 and STAT proteins ( the structure of the CRL4A SV5V complex is pictured in the inset )-thus inducing STAT1 ubiquitination and degradation
34.
There is precedent for a simian virus'lurking in polio vaccine : millions of Americans were inadvertently infected with such a virus, SV-40, in the 1950's and early 1960's . ( Fortunately, it was not harmful . ) But in 1967, several laboratory workers in Germany died from the newly discovered Marburg virus after it had been imported in African green monkeys.
35.
Last year, in his book, " The River, " a British journalist, Edward Hooper, advanced the provocative theory that such a vaccine might have been made with chimpanzee tissue contaminated with an ancestor of the virus that was to cause AIDS . The theory is based in part on the general scientific belief that HIV-1 derives from a simian virus in chimpanzees.
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