31. Depending on the R substituent , the exterior of cage can be further modified. 32. Another change is the replacement of the 5-phenyl chlorine substituent by bromine. 33. The substituent and molecular weight of the polymer influences the electronic properties of polysilane. 34. The variable-substituent relation is homogeneous in that it relates types to types. 35. A methyl ester substituent was reported in 1958. 36. The larger the substituent , the greater the selectivity for the ?-receptor. 37. When the substituent is axial, it is brought near to an axial gamma hydrogen. 38. When the substituent is n-butyl the reaction product is the classical Perkow adduct. 39. Those compounds with the 4-propionoxy substituent appear to be the most potent analgesics. 40. A small R 1 substituent is necessary to maintain the rapid oral bioavailability of triptans.
