Recently, PTPN22 has been associated with multiple autoimmune diseases including Type I diabetes, rheumatoid arthritis, systemic lupus erythematosus, Hashimoto s thyroiditis, Graves disease, Addison s disease, Myasthenia Gravis, vitiligo, systemic sclerosis juvenile idiopathic arthritis, and psoriatic arthritis.
32.
Symptoms of connective tissue diseases _ which include rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis _ can include pain and swelling of joints, swollen glands or lymph nodes, unexplained fatigue, excessive hair loss, memory problems and headaches.
33.
In autoimmune rheumatic diseases, impaired tolerance leads to the development of diseases such as rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, Sjogren s syndrome, etc . Therefore, in autoimmune diseases the converse strategy of engaging immunological checkpoints may be beneficial : stimulate inhibitory molecules of the immune system, thus inhibiting the immune system ( therefore, increase self-tolerance ).
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It has long been recognized that patients with ILD related to asbestos exposure, drugs ( such as chemotherapeutic agents or nitrofurantoin ), rheumatoid arthritis and scleroderma / systemic sclerosis may be difficult to distinguish from IPF . Other differential diagnostic considerations include interstitial lung disease related to mixed connective tissue disease, advanced sarcoidosis, chronic hypersensitivity pneumonitis, pulmonary Langerhan s cell histiocytosis and radiation-induced lung injury.
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