Thalamocortical oscillation involves the synchronous firing of thalamic and cortical neurons at specific frequencies; in the thalamocortical system, the exact frequencies depend on current brain state and mental activity.
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At the NYU School of Medicine, Poyiadjis formed three companies ( NeuroResonance LLC, NeuroControl Systems LLC, NeuroInterface LLC ) that are commercialising drugs and devices to suppress thalamocortical dysrhythmia.
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In one study, knockout mice lacking mGlu4 receptors showed a distruption of glutamate and GABA release in the thalamocortical network and were resistant to absence seizures induced by low does of pentylenetetrazole.
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Because pain can involve sensory, emotional and cognitive factors, leaving it " impossible to know " when painful experiences are perceived, even if it is known when thalamocortical connections are established.
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This work is aimed at understanding how human social interaction is mediated by metastability of neural networks . fMRI and EEG are particularly useful in mapping thalamocortical response to social cues in experimental studies.
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Metabotropic glutamate receptors ( mGluRs ) in the thalamocortical network have also shown to display some role in the generation of spike-and-wave discharges ( SWDs ) associated with absence epilepsy.
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Some studies have suggested that disruption of the auditory thalamocortical projections give rise to hallucinations, while dysregulated corticostriatal circuitry and reward circuitry in the form of aberrant salience can give rise to delusions.
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This disorder is associated with diseases and conditions such as neuropathic pain, tinnitus, and Parkinson's disease and is characterized by the presence of unusually low-frequency resonance in the thalamocortical system.
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A second theory of metastability involves a so-called "'dynamic core "', which is a term to loosely describe the thalamocortical region believed to be the integration center of consciousness.
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The brain stem and limbic system take care of essential body functioning and survival, while the thalamocortical system receives signals from sensory receptors and sends out signals to voluntary muscles such as those of the arms and legs.
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