They are the leading cause of endocrine-based infertility, as either hyperactivity or hypoactivity of the theca cells can lead to fertility problems; hyperactivity of theca cells causes hyperandrogenism, and hypoactivity leads to a lack of estrogen.
32.
They are the leading cause of endocrine-based infertility, as either hyperactivity or hypoactivity of the theca cells can lead to fertility problems; hyperactivity of theca cells causes hyperandrogenism, and hypoactivity leads to a lack of estrogen.
33.
In addition, theca cells predominantly secrete the relatively weak androgen androstenedione, whereas granulosa cells, signaled to do so by FSH under normal circumstances, convert androstenedione into its more potent relative testosterone ( which is subsequently converted into estradiol ).
34.
Due in part to elevated LH levels, which stimulate androgen production by theca cells in the paracrine factors ( but possibly including inhibin B ), has been shown to significantly enhance the LH-mediated stimulation of androgen production by theca cells.
35.
Due in part to elevated LH levels, which stimulate androgen production by theca cells in the paracrine factors ( but possibly including inhibin B ), has been shown to significantly enhance the LH-mediated stimulation of androgen production by theca cells.
36.
The theca cells are responsible for the production of androstenedione, and indirectly the production of 17? estradiol, also called E2, by supplying the neighboring granulosa cells with androstenedione that with the help of the enzyme aromatase can be used as a substrate for this type of estradiol.
37.
Because P450scc and StAR are also essential for sex steroid synthesis in the testis and ovary, the production of testosterone by Leydig cells in the testis and androgen ( which leads to estrogen production by granulosa cells ) and progesterone by ovarian theca cells and luteal cells, respectively, can also be impaired.
38.
As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone ( and indirectly estradiol ), whereas FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles, as well as stimulating production of estrogen by the ovaries.
39.
The dispersal of luteinized theca cells throughout the ovarian stroma, in contrast to PCOS where the luteinized theca cells are only around cystic follicles, causes women with hyperthecosis to have higher testosterone levels and male-attributed characteristics ( virilization ) than women with PCOS . Excess levels of insulin in the blood, known as hyperinsulinemia, is also a characteristic of hyperthecosis.
40.
The dispersal of luteinized theca cells throughout the ovarian stroma, in contrast to PCOS where the luteinized theca cells are only around cystic follicles, causes women with hyperthecosis to have higher testosterone levels and male-attributed characteristics ( virilization ) than women with PCOS . Excess levels of insulin in the blood, known as hyperinsulinemia, is also a characteristic of hyperthecosis.
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