The collective effect of imipramine on these receptors is not thought to contribute to its therapeutic activity in the treatment of depression, although it is believed to account for mostly all of its side effects.
32.
Another innovative project by Dean, whilst she was in Manchester, was the establishment of a peripatetic day service with professionals visiting different community health centres and providing therapeutic activities and groups near to the clients'homes.
33.
Because of its authoritative community model, SHA uniquely assists families using a wide variety of therapeutic activities such as wilderness-style living, high and low ropes courses, individual therapy, team building activities, sports, devotionals, and equine therapy.
34.
As for bee pollen, which enthusiasts say cures conditions ranging from premature aging to chronic prostate disease, Tyler responds that " none of the identified constituents of pollen has been linked to any significant therapeutic activity ."
35.
In 2003 he became Professor of Creative and Life Writing at Goldsmiths College, London, and in 2008 he became Chair of The Reader Organisation, the UK centre for research and promotion of reading as a therapeutic activity.
36.
At the time of participation in the study, most of the patients had been taking part in a program of therapeutic activities _ for example, work or occupational therapy _ for several months without any improvement in symptoms.
37.
Their multidimensional scaling analysis represented the results on a two-dimensional graph, with one dimension representing hot processing versus cool processing ( roughly, closeness and emotional experience versus technical information and persuasion ) and the other dimension representing therapeutic activity.
38.
Although it is capable of producing significant central effects at high doses, doses within the normal therapeutic range generally do not notably impair cognition or proprioception, resulting in therapeutic activity roughly equatable to that of loperamide ( Imodium ).
39.
Nevertheless, Ms . Robbins-Roth added, " at the end of the day, you've still got the grunt work ahead, " meaning that companies that find relevant therapeutic activity with Genetics Institute's proteins will still have to find ways to make them into drugs, conduct clinical trials and clear regulatory hurdles.
40.
However, a recently completed phase-II clinical trial with brain-tumor patients yielded mixed outcomes; while there was some improved therapeutic activity when " O " 6-BG and temozolomide were given to patients with temozolomide-resistant anaplastic glioma, there seemed to be no significant restoration of temozolomide sensitivity in patients with temozolomide-resistant glioblastoma multiforme.
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