Factors III and VI are unassigned, as thromboplastin was never identified, and actually turned out to consist of ten further factors, and accelerin was found to be activated Factor V.
32.
Although sometimes used as a synonym for the protein tissue factor ( with its official name " Coagulation factor III [ thromboplastin, tissue factor ] " ), this is a misconception.
33.
Notably, when one examines the lab values in Vitamin K deficiency [ see below ] the prothrombin time is elevated, but the partial thromboplastin time is normal or only mildly prolonged.
34.
The contact activation ( intrinsic ) pathway is initiated by activation of the " contact factors " of plasma, and can be measured by the activated partial thromboplastin time ( aPTT ) test.
35.
Other tests performed in any patient with bleeding problems are a complete blood count ( especially platelet counts ), activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen level.
36.
The INR was coupled to Dr Kirkwood's simultaneous invention of the International Sensitivity Index ( ISI ), which provided the means to calibrate different batches of thromboplastins to an international standard.
37.
Measurement of HMWK is usually done with mixing studies, in which plasma deficient in HMWK is mixed with the patient's sample and a partial thromboplastin time ( PTT ) is determined.
38.
The classical coagulation tests such as PT ( prothrombin time ), aPTT ( activated partial thromboplastin time ) or thrombin time are not very sensitive for hyperfibrinolysis, and influenced by numerous other variables.
39.
Partial thromboplastin time ( PTT ) measures the overall speed at which blood clots by means of two consecutive series of biochemical reactions known as the " intrinsic " ( now referred to as the contact activation pathway ) and common coagulation pathways.
40.
Complete thromboplastin consists of tissue factor, phospholipids ( since platelets were removed from blood sample being tested ), and CaCl 2 to reintroduce calcium ions which were chelated by sodium citrate originally used to prevent coagulation of the sample blood during transportation and / or storage.
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