Tsetse flies have an arsenal of immune defenses to resist each stage of the trypanosome infectious cycle, and thus are relatively refractory to trypanosome infection Among the host flies defenses is the production of hydrogen peroxide, a reactive oxygen species that damages DNA . These defenses limit the population of infected flies.
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His current research interests include : 1 ) Studying the function and regulation of a group of enzymes called phospholipase A2 that are involved in lipid mediator biosynthesis related to inflammation; 2 ) Anti-malaria and anti-trypanosome drug discovery; 3 ) New technology for the newborn screening of enzyme deficiency diseases including lysosomal storage diseases.
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However, the specific type of the trypanosome differs according to geography . " T . b . rhodesiense " is found primarily in East Africa ( Botswana, Ethiopia, Kenya, Malawi, Tanzania, Uganda, Zaire, and Zimbabwe ), while " T . b . gambiense " is found in Central and West Africa.
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The formation of mosaic " VSG " s allows the ( partial ) expression of pseudogene " VSG " s, which can constitute the major portion of the " VSG " archive, and can contribute directly to antigenic variation, vastly increasing the trypanosome's capacity for immune evasion and potentially posing a major problem for vaccine development.
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