31. Tunicates lack the kidney-like urate crystals, and do not have any obvious means of disposing of the material during their lifetimes. 32. A PEGylated form of urate oxidase is in clinical development for treatment of chronic hyperuricemia in patients with " treatment-failure gout ". 33. The systematic name of this enzyme class is "'urate -ribonucleotide : phosphate alpha-D-ribosyltransferase " '. 34. The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. 35. The protein encoded by this gene is a urate transporter and urate -anion exchanger which regulates the level of urate in the blood. 36. The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. 37. The enzyme is a homodimer, and requires urate , and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. 38. The urates often form a separate white blob, as anyone who has worn a new hat outdoors at the wrong time has probably noticed. 39. After confirmation of lysosome, de Duve's team was troubled by the existence of another enzyme urate oxidase in rat liver cell fraction. 40. Urate oxidase is found in nearly all organisms, from bacteria to mammals, and plays different metabolic roles, depending on its host organism.
