The vasodilatation, caused by sodium nitroprusside, has been shown to be mediated not only by NO generation, but also by endogenous cyanide generation, which adds not only toxicity, but also some additional antihypertensive efficacy compared to nitroglycerine and other non-cyanogenic nitrates which do not cause blood cyanide levels to rise.
32.
However, the changes in arterial diameter and in wall tension due to vasoconstriction and vasodilatation make a long-term measurement with this single control loop almost impossible, since the true unloading of the arterial wall is easily lost Therefore, groups in the Netherlands, Japan, Australia and Austria have improved the PeH�z principle of vascular unloading.
33.
The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell Fc?RI receptors . smooth muscle cells causing contraction ( leading to the airway narrowing seen in allergic asthma ), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema.
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