Agents commonly used in induction and for stem cell transplant conditioning are platinum compounds ( cisplatin, carboplatin ), alkylating agents ( cyclophosphamide, ifosfamide, melphalan ), topoisomerase II inhibitor ( etoposide ), anthracycline antibiotics ( doxorubicin ) and vinca alkaloids ( vincristine ).
32.
In contrast to colchine and vinca alkaloids, paclitaxel enhances microtubule polymerization promoting both the nucleation and elongation phases of the polymerization reaction, and it reduces the critical tubulin sub-unit concentration ( i . e ., soluble tubulin concentration at steady-state ).
33.
It may also be used in the augmented production of secondary metabolites such as the vinca alkaloids Vincristine and Vinblastine in the rosy periwinkle ( " Catharanthus roseus " ), whereby space grown specimens often have higher concentrations of these constituents that on earth are present in only trace amounts.
34.
"' Vincaminol "'( C 20 H 26 N 2 O 2 ) is a chemical that is a part of the Vinca alkaloid group, which were discovered in the 1950s by a Canadian scientist and are derived from " Vinca minor " ( periwinkle ).
35.
It gave rise to the so-called ADE ( or DAE = DA + etoposide ) induction regimen in AML . The ADE induction ( unlike, say, combinations of 7 + 3 with vinca alkaloids or prednisolone ) is still sometimes used, especially in poor-risk AML patients.
36.
The addition of vinca alkaloids ( vincristine or vinblastine ) to the " 7 + 3 " regimen, which addition was quite popular in AML in old times ( when the biology of AML and the differences between AML and ALL was poorly understood ) proved to be harmful in AML, lowering the chance of the patient to get remission.
37.
Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin . and optic neuropathy, which is most common after several months of treatment and may also be irreversible.
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