If a normal internal uterus, cervix and upper vagina ( the M�llerian derivatives ) exist, and the outer virilization is modest, surgery involves separating the fused labia and widening the vaginal introitus.
32.
The "'clitoral index "', defined as the product of the sagittal and transverse dimensions of the glans clitoridis, is sometimes used as a measure of virilization in women.
33.
AR antagonists may not bind to or block membrane androgen receptors ( mARs ), which are distinct from the classical nuclear AR . However, the mARs do not appear to be involved in virilization.
34.
Women who are administered oxandrolone may experience virilization, the non-reversible development of masculine features such as voice deepening, hirsutism, menstruation abnormalities, male-pattern hair loss, and clitoral enlargement.
35.
Instead, androgens will elevate once again above normal levels, and may cause additional virilization, such as acne, hirsutism, and further enlargement of the clitoris, unless treatment with estrogen is given.
36.
De novo ( i . e . a somatic mutation ); a certain amount of the wild-type androgen receptor will be present in cases of somatic mutation, which can induce virilization at puberty.
37.
No additional testosterone is given during childhood, to avoid unwanted virilization and bone maturation . ( There is also some evidence that premature administration of testosterone can lead to reduced penis size in the adult .)
38.
The challenge of preventing severe virilization of girls is twofold : detection of CAH at the beginning of the pregnancy, and delivery of an effective amount of glucocorticoid to the fetus without causing harm to the mother.
39.
Many of the myths stem from high-dose testosterone treatments for other, unrelated medical conditions, which can cause virilization _ growth of facial hair, loss of scalp hair, deepening of the voice and weight gain.
40.
Use of the patch resulted in virilization in five men who had never gone through puberty, including a 51-year-old man who developed pubic and facial hair and an enlarged penis for the first time in his life.
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