The more virilized phenotypes of AIS have sometimes been described as " undervirilized male syndrome ", " infertile male syndrome ", " undervirilized fertile male syndrome ", etc ., before evidence was reported that these conditions were caused by mutations in the " AR " gene.
32.
While a boy ( or girl ) with simple virilizing CAH is taller than peers at that point, he will have far fewer years remaining to grow, and may go from being a very tall 7-year-old to a 62-inch 13-year-old who has completed growth.
33.
As their name suggests, AAS have two different, but overlapping, types of effects : " anabolic ", meaning that they promote anabolism ( cell growth ), and " androgenic " ( or " virilizing " ), meaning that they affect the development and maintenance of masculine characteristics.
34.
The lack of virilizing effects means that S-40503 may even be suitable for use in women, which would be a substantial advantage over existing drugs as women tend to be more likely to suffer from osteoporosis, and are generally contraindicated from taking anabolic steroids due to the risk of side effects such as masculinisation and hirsutism.
35.
Because AMH expression is critical to sex differentiation at a specific time during fetal development, it appears to be tightly regulated by SF1, GATA factors, DAX1 and FSH . Mutations in both the AMH gene and the type II AMH receptor have been shown to cause the persistence of M�llerian derivatives in males that are otherwise normally virilized.
36.
This suggests that, while SARMs are likely to show some virilizing effects when used at high doses ( e . g ., use by bodybuilders ), at lower therapeutic doses they may well be effectively selective for anabolic effects, which will be important if SARMs are to have clinical application in the treatment of osteoporosis in women.
37.
"' 11?-Hydroxylase deficient congenital adrenal hyperplasia "'( "'11?-OH CAH "') is an uncommon form of congenital adrenal hyperplasia ( CAH ) resulting from a defect in the gene encoding the enzyme steroid 11?-hydroxylase which mediates the final step of cortisol synthesis in the virilize a genetically female fetus or a child of either sex.
38.
In all its forms, congenital adrenal hyperplasia due to 21-hydroxylase deficiency accounts for about 95 % of diagnosed cases of CAH . Unless another specific enzyme is mentioned, " CAH " in nearly all contexts refers to 21-hydroxylase deficiency . ( The terms " salt-wasting CAH ", and " simple virilizing CAH " usually refer to subtypes of this condition . ) CAH due to deficiencies of enzymes other than 21-hydroxylase present many of the same management challenges as 21-hydroxylase deficiency, but some involve mineralocorticoid excess or sex steroid deficiency.
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