Because of this low volume of distribution, it can be concluded that the medicine is thought to be confined in the plasma or liquid parts of the blood.
32.
The volume of distribution ( V d ) of lacosamide in plasma is 0.6 L / kg, which is close to the total volume of water.
33.
They are highly protein-bound in plasma ( typically > 95 % ), usually to albumin, so that their volume of distribution typically approximates to plasma volume.
34.
After being taken by mouth it is rapidly absorbed by the GI tract ( although absorption through the stomach is negligible ); its volume of distribution is roughly 50 L.
35.
However, if we do not make the initial volume of distribution vanishingly small, then we assume an instant mixing drug delivery in whatever volume the drug is delivered into.
36.
In dog testing, this compound with a carboxamide group called 13F, showed a great pharmacokinetical profile, a low clearance and adequate half-life and volume of distribution.
37.
Forced diuresis, hemodialysis, exchange transfusion, or hemoperfusion are unlikely to be of benefit in hastening the removal of venlafaxine, due to the drug's high volume of distribution.
38.
A metabolite of chloroquine hydroxycloroquine has a long half-life ( 32 56 days ) in blood and a large volume of distribution ( 580 815 L / kg ).
39.
It has a plasma half-life of 22min, mean clearance rate of 274 mL / kg / min, and apparent volume of distribution of 880 ?150 mL / kg.
40.
Clearance of a substance is sometimes expressed as the inverse of the time constant that describes its removal rate from the body divided by its volume of distribution ( or total body water ).
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