Later, it was purified from human skin ( 1968 ), and was recognized to be synthesized as a zymogen.
32.
Zymogens are large, inactive structures, which have the ability to break apart or change into the smaller activated enzymes.
33.
In the absence of Mist1, exocrine tissue shows improper organization of organelles, especially the localization of the zymogen granules.
34.
Accidental activation of zymogens can happen when the secretion duct in the pancreas is blocked by a gallstone resulting in acute pancreatitis.
35.
To be specific, tPA cleaves the zymogen plasminogen at its Arg561-Val562 peptide bond, into the serine protease plasmin.
36.
After this reaction occurs, the zymogen form of the protease is then processed into its active form, ?-acrosin.
37.
The difference between zymogens and the activated enzymes lies in the fact that the active site for catalysis of the zymogens is distorted.
38.
The difference between zymogens and the activated enzymes lies in the fact that the active site for catalysis of the zymogens is distorted.
39.
Trypsinogen is stored in intracellular vesicles in the pancreas called zymogen granules whose membranous walls are thought to be resistant to enzymatic degradation.
40.
Activation of the matriptase zymogen requires sequential N-terminal cleavage, activation site autocleavage, and transient association with HAI-1.
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