41. Cortisol and ACTH kick off the cascade, so they are reliable indicators of stress. 42. Here the pituitary releases adrenocorticotropic hormone ( ACTH ) which ultimately stimulates the release of cortisol. 43. This causes the blood ACTH levels to be elevated along with cortisol from the adrenal gland. 44. Administration of corticotropin releasing hormone ( CRH ) can differentiate this condition from ectopic ACTH secretion. 45. A CT or MRI of the pituitary may also show the ACTH secreting tumor if present. 46. It may worsen edema when taken alongside adrenal cortical steroids or adrenocorticotropic hormone ( ACTH ). 47. B-50 was regulated by the pituitary peptide ACTH and was associated with grooming behavior. 48. In some cases, actual cause of low ACTH is from low CRH in the hypothalamus. 49. Dogs who do not have Addison's disease will have normal values on ACTH tests. 50. Verucerfont blocks the CRH-1 receptor, and so reduces ACTH release following chronic stress.