More specifically, from a strictly scientific point of view, statistically estimated predictions, such as MET or BMI, are inaccurate when used for specific persons, and MET values must be treated as indicative only, taking into account that both RMR and actual energy consumption are highly dependent on physical and environmental factors such as adiposity, physical fitness level, cardiovascular health, or even ambient temperature.
42.
First, unlike subcutaneous adipose tissue, visceral adipose cells produce significant amounts of proinflammatory cytokines such as tumor necrosis factor-alpha ( TNF-a ), and Interleukins-1 and-6, etc . In numerous experimental models, these proinflammatory cytokines disrupt normal insulin action in fat and muscle cells, and may be a major factor in causing the whole-body insulin resistance observed in patients with visceral adiposity.
43.
Insulin resistance often is found in people with visceral adiposity ( i . e ., a high degree of fatty tissue within the abdomen as distinct from subcutaneous adiposity or fat between the skin and the muscle wall, especially elsewhere on the body, such as hips or thighs ), hypertension, hyperglycemia, and dyslipidemia involving elevated triglycerides, small dense low-density lipoprotein ( sdLDL ) particles, and decreased HDL cholesterol levels.
44.
Insulin resistance often is found in people with visceral adiposity ( i . e ., a high degree of fatty tissue within the abdomen as distinct from subcutaneous adiposity or fat between the skin and the muscle wall, especially elsewhere on the body, such as hips or thighs ), hypertension, hyperglycemia, and dyslipidemia involving elevated triglycerides, small dense low-density lipoprotein ( sdLDL ) particles, and decreased HDL cholesterol levels.
45.
Centers : Center for Global Health ( WHO ); Center for Public Health Practice | Rocky Mountain Public Health Training Center ( HRSA ); Centers for American Indian & Alaska Native Health; Latino Research & Policy Center; Center for Health, Work & Environment ( NIOSH ); Rocky Mountain Prevention & Research Center; Center for Food Safety & the Prevention of Foodborne Disease ( CDC ); Colorado Biostatistics Consortium; Lifecourse Epidemiology of Adiposity & Diabetes; Program for Injury Prevention, Education & Research ( PIPER ).
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