41. Adverse effects in mammals are caused by amitraz'alpha-adrenergic agonist activity. 42. It is an ? 1a adrenergic receptor antagonist. 43. Carvedilol is both a non-selective alpha adrenergic receptor blocker ( ?1 ). 44. Penbutolol acts on the ?1 adrenergic receptors in both the heart and the kidney. 45. Various heterocyclic antidepressants and antipsychotics are ? 1-adrenergic receptor antagonists as well. 46. Beta-1 adrenergic receptor has been shown to interact with DLG4 and GIPC1. 47. Another way to inhibit adrenergic receptor signaling is by blocking the synthesis of catecholamines. 48. It is an ?-adrenergic receptor agonist that inhibits secretion of nasal mucus. 49. It also is an ?2-adrenergic agonist. 50. It is known to bind to non-adrenergic sites in pig kidney membranes.