Arsenic trioxide apparently works like another common APL treatment, retinoic acid : Instead of killing cells, it causes those immature white cells to mature into normal cells, Scheinberg said.
42.
Arsenic trioxide appears to be the most effective single drug against APL, which strikes about 1, 500 people in the United States and 2, 000 people elsewhere each year.
43.
For relapsed acute promyelocytic leukemia ( APL ), arsenic trioxide is approved by the US FDA . Like ATRA, arsenic trioxide does not work with other subtypes of AML.
44.
In the 1970s Chinese researcher Zhang TingDong and colleagues investigated the potential use of the traditionally used Chinese medicine arsenic trioxide to treat acute promyelocytic leukemia ( APL ).
45.
Also in the 1970s Chinese researcher Zhang TingDong and colleagues investigated the potential use of the traditionally used substance arsenic trioxide to treat acute promyelocytic leukemia ( APL ).
46.
_Numerous " boilovers, " such as one reported in 1988 when a " reactor " vat of arsenic trioxide overflowed during the manufacturing process, again causing a mass exodus.
47.
"In vitro " studies suggest that arsenic trioxide ( As 2 O 3 ) inhibits the proliferation of myeloma cells via cell cycle arrest as well as triggering cell death.
48.
They found that the yellow pigment was arsenic sulphide, and that when bleached by light, it becomes arsenic trioxide and separates from the linseed oil used to make the paints.
49.
During the 18th, 19th, and 20th centuries, a number of arsenic compounds were used as medicines, including arsphenamine ( by Paul Ehrlich ) and arsenic trioxide ( by Thomas Fowler ).
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The taxpayer-funded ( c . $ 900m to about a billion dollars ) remediation plan to permanently freeze the arsenic trioxide dust was approved by the Canadian federal government in August 2014.
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