41. Like some other benzyl compounds, the molecule undergoes directed ortho metalation with butyl lithium. 42. Myrophine is substituted with a 3-benzyl group and a 6-myristyl chain. 43. For example, the base catalyzed reaction of benzyl alcohol upon trichloroacetonitrile yields a trichloroacetimidate. 44. That provided optimum relative orientation of the benzyl and diketoacid ( DKA ) site chain. 45. This protecting group is chemically very similar to the less electron-rich benzyl ether. 46. Similarly, benzyl is a common ligand. 47. The revolutionary use of salicylate of benzyl was first experimented by Francis Fourbon 50 years ago. 48. Pure benzyl alcohol produces corneal necrosis. 49. Benzyl bromide is a strong lachrymator and is also intensely irritating to skin and mucous membranes.50. Benzyl chloride also reacts readily with metallic magnesium to produce a 1, 2-diphenylethane.
