41. Blood volume expanders will be replaced by blood substitutes.42. This approximates to the effective loss of blood volume . 43. EABV can be reduced in the setting of low, normal, or high actual blood volume . 44. The product, known as a blood volume plasma expander, helps replace blood lost during major surgery. 45. Blood pressure goes up after giving blood, as the body compensates for the missing blood volume . 46. As a result, their blood volume is reduced. 47. A number of companies are working on blood volume expanders to maintain blood volume during surgeries. 48. A number of companies are working on blood volume expanders to maintain blood volume during surgeries. 49. The apheresis procedure typically lasts for 4 6 hours, depending on the donors total blood volume . 50. The estimated blood volume in adult animals is 55 to 70 ml / kg body weight.