The pertussis toxin ( also an AB 5 protein ) produced by " Bordetella pertussis " acts in a similar manner with the exception that it ADP-ribosylates the G? " i " subunit, rendering it inactive and unable to inhibit adenylyl cyclase production of cAMP ( leading to constitutive production ).
42.
In " Bordetella pertussis ", the infectious agent in childhood whooping cough, filamentous haemagglutinin ( FHA ) is a surface-exposed and secreted protein that acts as a major virulence attachment factor, functioning as both a primary adhesin and an immunomodulator to bind the bacterial to beta-strands separated by beta-turns.
43.
There are multiple causative agents, the most common being the bacterium " Bordetella bronchiseptica " ( found in 78.7 % of cases in Southern Germany ), followed by canine parainfluenza virus ( 37.7 % of cases ), and to a lesser extent canine coronavirus ( 9.8 % of cases ).
44.
One difference between the different species of " Bordetella " is that " B . pertussis " produces PT and the other species do not . " Bordetella parapertussis " shows the most similarity to " B . pertussis " and was therefore used for research determining the role of PT in causing the typical symptoms of whooping cough.
45.
One difference between the different species of " Bordetella " is that " B . pertussis " produces PT and the other species do not . " Bordetella parapertussis " shows the most similarity to " B . pertussis " and was therefore used for research determining the role of PT in causing the typical symptoms of whooping cough.
46.
In animal models, passive immunization with anti FimH-antibodies and vaccination with the protein significantly reduced colonization by UPEC . Moreover, the " Bordetella pertussis " adhesins FHA and pertactin are components of 3 of the 4 acellular pertussis vaccines currently licensed for use in the U . S . Additionally, anti-adhesion vaccines are being explored as a solution to E . coli " in mice.
47.
""'Bordetella avium " "'is a Gram-negative, aerobic, motile bacterium from the genus " Bordetella " which has been isolated from patients with respiratory disease ( cystic fibrosis ) . " B . avium " is mainly responsible for the animal disease bordetellosis in wild and domesticated birds . " B . avium " was first described as " Alcaligenes faecalis ".
48.
""'Bordetella avium " "'is a Gram-negative, aerobic, motile bacterium from the genus " Bordetella " which has been isolated from patients with respiratory disease ( cystic fibrosis ) . " B . avium " is mainly responsible for the animal disease bordetellosis in wild and domesticated birds . " B . avium " was first described as " Alcaligenes faecalis ".
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