41. In the long term, it can stave off the brittle bones of osteoporosis that can lead to life-threatening injuries. 42. This treatment substantially reduces the incidence of osteoporosis, a brittle bone disease that is a major cause of disability. 43. The hormones are also known to reduce the risk of heart disease, brittle bones and possibly even mental decline. 44. Shindell said it may be impossi ble to calculate the odds of quadru plets suffering from brittle bone disorder. 45. This occurs either through inaccurate implant placement or if the fixation does not hold in weak and brittle bone . 46. Allen, 2 1 / 2, suffers from a rare genetic bone defect called osteogenesis imperfecta, or brittle bone disease. 47. The procedure, however, doesn't effectively rid the blood of phosphorus, which can lead to brittle bones and other complications. 48. Estrogen's benefits may still outweigh its hazards for women who are at high risk of heart trouble and brittle bones . 49. Following his most recent surgery, in October, he used an aquatics-based rehabilitation program to avoid pounding on the brittle bones . 50. Autosomal dominant osteopetrosis shows mild symptoms in adults experiencing frequent bone fractures due to brittle bones { Michigami, 2002 }.