41. Narlaprevir does not bind to human proteases, with the exception of cathepsin B ( 69 % inhibition ). 42. Cathepsin S participates in the degradation of the invariant or Ii chain that prevents loading the antigen into the complex.43. Cathepsin Z has been shown to MSN, MTUS2, NOTCH2NL, PLK2, PLSCR1, SGOL2, and SPRED2.44. Very small amounts of enzymatic activity can be elucidated and is capable of resolving a femtomole of cathepsin K activity. 45. There are, however, exceptions such as cathepsin K, which works extracellularly after secretion by osteoclasts in bone resorption. 46. Cathepsin K is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness.47. The translated prepro-cathepsin C is processed into the mature form by at least four cleavages of the polypeptide chain. 48. Cathepsin D "'is a protein that in humans is encoded by the " CTSD " gene.49. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. 50. This disease is due to mutations in the CTSA gene which encodes the protective protein / cathepsin A ( PPCA ).
