41. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. 42. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. 43. In that case, a crossover event will result in one chromosome with two centromeres and an acentric fragment. 44. The checkpoint is held active by any unattached centromere ; only when all centromeres are attached will anaphase commence. 45. The checkpoint is held active by any unattached centromere; only when all centromeres are attached will anaphase commence. 46. Most organisms, ranging from the fission yeast " Schizosaccharomyces pombe " to humans, have regional centromeres . 47. FRT sites have been inserted transgenically near the centromere of each chromosome arm of " Drosophila melanogaster ". 48. Chromoviruses from each clade show distinctive integration patterns, e . g . into centromeres or into the rRNA genes. 49. The complexes containing the duplicated DNA molecules, the sister chromatids, are attached to each other by the centromere . 50. :The centromere is the chromosomal site that organises and regulates the machinery responsible for chromosome segregation to daughter cells.