Following chlordiazepoxide, diazepam marketed by Hoffmann La Roche under the brand name " Valium " in 1963, and for a while the two were the most commercially successful drugs.
42.
Laboratory tests assessing the toxicity of chlordiazepoxide, nitrazepam and diazepam on mice spermatozoa found that chlordiazepoxide produced toxicities in sperm including abnormalities involving both the shape and size of the sperm head.
43.
Laboratory tests assessing the toxicity of chlordiazepoxide, nitrazepam and diazepam on mice spermatozoa found that chlordiazepoxide produced toxicities in sperm including abnormalities involving both the shape and size of the sperm head.
44.
In a 1991 study, triazolam had the highest self-administration rate in cocaine trained baboons, among the five benzodiazepines examined : alprazolam, bromazepam, chlordiazepoxide, lorazepam, triazolam.
45.
If used in pregnancy, those benzodiazepines with a better and longer safety record, such as diazepam or chlordiazepoxide, are recommended over potentially more harmful benzodiazepines, such as temazepam or triazolam.
46.
The study tested and compared the abuse liability of temazepam, triazolam, diazepam, lorazepam, oxazepam, flurazepam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam, flunitrazepam, bromazepam, and clorazepate.
47.
*BNF page numbers have only just become available today, so I expect people will be checking them over the next few days . Could diazepam and chlordiazepoxide be included in the " Pharmacokinetics " section?
48.
Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse liability, while oxazepam, halazepam, and possibly chlordiazepoxide, are relatively low in this regard.
49.
A follow-up study using the same species confirmed the anxiolytic effect of chlordiazepoxide, but moreover, the intensity of the anxiety-like behaviour was dependent on the intensity of the electric shock until reaching a plateau.
50.
*Much is made of the half-lives of chlordiazepoxide and diazepam in the article, but they are not included in the " Pharmacokinetics " section . talk ) 09 : 08, 22 June 2009 ( UTC)
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