While warfarin and heparin have their major effects on coagulation factors, an increased bleeding time is sometimes seen with use of these medications as well.
42.
The possibility of an extra coagulation factor was initially resisted on methodological grounds by Drs Armand Quick and Walter Seegers, both world authorities in coagulation.
43.
These increases in coagulation factors may contribute to the development of stroke ( see under side-effects ), but a precise association cannot be made at this stage.
44.
Coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption.
45.
One can get a clue as to whether bleeding is due to a platelet disorder or a coagulation factor disorder by the characteristics and location of the bleeding.
46.
Human Factor XII is 596 amino acids long and consists of two domains, the heavy chain ( 353 domain of coagulation factor XII was solved by x-ray crystallography.
47.
Also under development are other small molecular compounds that interfere directly with the enzymatic action of particular coagulation factors ( e . g ., rivaroxaban, dabigatran, apixaban ).
48.
Coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption.
49.
Coagulopathy is another cardinal feature of ALF . The liver has the central role in the synthesis of almost all coagulation factors and some inhibitors of coagulation and fibrinolysis.
50.
In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells.
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