For example, cyanocobalamin can be converted to its analog cobalamins via reduction to, followed by the addition of the corresponding alkyl halides, acyl halides, alkene or alkyne.
42.
Cobalamin analogs prepared by this method include the naturally occurring coenzymes methylcobalamin and cobamamide, and other cobalamins that do not occur naturally, such as vinylcobalamin, carboxymethylcobalamin and cyclohexylcobalamin.
43.
Cobalamin analogs prepared by this method include the naturally occurring coenzymes methylcobalamin and cobamamide, and other cobalamins that do not occur naturally, such as vinylcobalamin, carboxymethylcobalamin and cyclohexylcobalamin.
44.
Vitamin B12 ( cobalamins ) contain a corrin ring similar in structure to porphyrin and is an essential coenzyme for the catabolism of fatty acids as well for the biosynthesis of methionine.
45.
Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD ( MMADHC ), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin.
46.
Thus, one review states : " Altogether it can be concluded that an observed elevation of cobalamin in blood merits a full diagnostic work up to assess the presence of disease ."
47.
Cobalt is the active center of coenzymes called cobalamins, the most common example of which is vitamin B . As such, it is an essential trace dietary mineral for all animals.
48.
The disorder may be distinguished from the re-methylation defects ( e . g ., MTHFR, methionine synthase deficiency and the cobalamin defects ) in lieu of the elevated methionine concentration.
49.
These include chlorin, which has a magnesium atom in several types of chlorophyll; bacteriochlorin, found in bacteriochlorophyll; and corrin, which has a cobalt atom in cobalamin or vitamin B12.
50.
If the patient has inborn errors in the methyltransfer pathway ( cobalamin C disease, combined methylmalonic aciduria and homocystinuria ), treatment with intravenous, intramuscular hydroxocobalamin or transdermal B 12 is needed.
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