41. The safety of microbial drug delivery is tied to the microbes commensal capability and instance of pathogenesis. 42. The dog is a classic example of a domestic animal that likely traveled a commensal pathway into domestication. 43. The commensal lactobacilli of the vagina produce lactic acid, and the cervix likewise is hostile to pathogens. 44. In India, lone jackals expelled from their pack have been known to form commensal relationships with tigers. 45. However, under special conditions commensal streptococci can become opportunistic pathogens, initiating disease and damaging the host. 46. In the north Atlantic Ocean, oyster crabs may live in an commensal relationship within a host oyster. 47. It is commonly believed to be a commensal organism ( dependent upon its human host for survival ). 48. A survival strategy for any infectious agent is not to kill its host but ultimately become a commensal organism. 49. In animals, it can originate fulminant septicaemia ( chicken cholera ), but is also a common commensal . 50. Secondly, helminths, non-pathogenic ambient pseudocommensal bacteria or certain gut commensals and probiotics, drive immunoregulation.