The oocyte has been shown to obtain maximum proficiency for releasing calcium at this same cell stage, between metaphase I and metaphase II, as well, further emphasizing the calcium-dependency of the cortical granule exocytosis event.
42.
This itself triggers the cortical reaction, which results in depositing several substances onto the vitelline membrane through exocytosis of the cortical granules, transforming it into a hard layer called the fertilization membrane , which serves as a barrier inaccessible to other spermatozoa.
43.
The cortical reaction within the egg is analogous to the acrosomal reaction within the sperm, where the acrosome, a specialized secretory vesicle that is homologous to cortical granules, is fused with the plasma membrane of the sperm cell to release its contents which degrade the egg's tough coating and allow the sperm to bind to and fuse with the egg.
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