41. This legume is commonly named for its sweet smell, which is due to the presence of coumarin in its tissues. 42. A : The Food and Drug Administration does not recommend buying Mexican vanilla since it often contains coumarin , a blood thinner. 43. Coumarin was banned as a food additive in the United States in 1954, largely because of the hepatotoxicity results in rodents.44. Overall, a 1.9 ( 90 % ) increase in minor neurological dysfunction was observed for children exposed to coumarin . 45. The toxicity of coumarin in a minority of people is apparently related to its non-conventional metabolism to produce an hepatotoxin. 46. Karl Link continued working on developing more potent coumarin -based anticoagulants for use as rodent poisons, resulting in warfarin in 1948. 47. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. 48. Dr . Wigand later stated that coumarin itself is dangerous, pointing out that the FDA had banned its addition to human food in 1954. 49. Other mechanisms include de novo synthesis of a coumarin -resistant gyrase B subunit by the novobiocin producer " S . sphaeroides ". 50. It is likely that the baking soda wash you used for the browning caused the coumarin in the cinnamon to take on a green palour.
