GSH may be increased by different methods including delivery of L-Cystine, a rare limiting amino acid in GSH synthesis.
42.
This gene encodes a cytokine member of the cystine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region.
43.
SLC7A11 is a member of a heterodimeric Na +-independent anionic amino acid transport system highly specific for cystine and glutamate.
44.
CAP domain is 15 KDa structurally conserved cystine rich domain as was historically referred to as SCP, NCBI cd00168 pr Pfam00188.
45.
Ferroptosis plays a role in physiological and pathological cell death events such as kidney failure, iron overload, and cystine deprivation.
46.
These roles are typically limited to the intracellular milieu, where the environment is reducing, and cysteine is not oxidized to cystine.
47.
Cystinosis is caused by mutations in the " endocytosed protein to cystine within lysosomes, it is normally transported to the cytosol.
48.
Increased intracellular cystine profoundly disturbs cellular oxidative metabolism and glutathione status, leading to altered mitochondrial energy metabolism, autophagy, and apoptosis.
49.
The accumulation is caused by abnormal transport of cystine from lysosomes, resulting in a massive intra-lysosomal cystine accumulation in tissues.
50.
The accumulation is caused by abnormal transport of cystine from lysosomes, resulting in a massive intra-lysosomal cystine accumulation in tissues.
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