41. Several natural product drugs target tubulin, which is a component of the cytoskeleton . 42. It may be attached to the microfilament cytoskeleton . 43. It generally involves drastic changes in cell shape which are driven by the cytoskeleton . 44. In addition, the secretions stimulate fibroblast proliferation and rearrangement of the actin cytoskeleton . 45. Transformation can also affect the cytoskeleton and change in the quantity of signal molecules. 46. Attachment of the cytoskeleton to the substratum is required to generate a directional movement. 47. Even after the microtubules have stabilized, the cytoskeleton of the neuron remains dynamic. 48. Ankyrin 1 links membrane receptor CD44 to the inositol triphosphate receptor and the cytoskeleton . 49. DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. 50. PAK5 phosphorylation of p120-catenin at S288 plays a role in cytoskeleton remodeling.