Other bioactive RiPPs include the antibiotics cyclothiazomycin and bottromycin, the ultra-narrow spectrum antibiotic plantazolicin, and the cytotoxin patellamide A . Streptolysin S, the toxic virulence factor of " Streptococcus pyogenes ", is also a RiPP . Additionally, human thyroid hormone itself is a RiPP due to its biosynthetic origin as thyroglobulin.
42.
Other proteins belonging to the pancreatic ribonuclease superfamily include : bovine seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases; liver-type ribonucleases; angiogenin, which induces vascularisation of normal and malignant tissues; eosinophil cationic protein, a cytotoxin and helminthotoxin with ribonuclease activity; and frog liver ribonuclease and frog sialic acid-binding lectin.
43.
Of negative biosafety aspects tested, it was shown that there was no production of enterotoxins ( Shiga toxins, heat-stable and heat-labile toxins ), no production of cytotoxins ( CNF ), no invasiveness, no pathogenic adhesion factors ( e . g . no CFA I / II, P, M and S fimbriae ), no hemolysins, no serum resistance ( i . e . no risk of sepsis ), no uropathogenicity and no antibiotic-resistance genes.
44.
Elsewhere in Japan, in 1975 Fujisawa pharmaceutical company observed that the extract of a black sponge, " Halichondria okadai ", was a potent cytotoxin, and was dubbed Halichondrine-A . In 1981, the structure of one such toxin, okadaic acid, was determined after it was extracted from both the black sponge in Japan, " Halichondria okadai ", for which it was named, and a sponge in the Florida Keys, " Halichondria Melanodocia ".
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