41. This damage might arise in the course of a variety of neurological conditions that involve demyelination and bilateral corticobulbar lesions. 42. As such, the demyelination process affects the communication between neurons and this consequently affects the neural pathways they control. 43. In addition, the herpes simplex virus type 1 ( HSV-1 ) infection is associated with demyelination of nerves. 44. The accumulated and embedded VLCFA in the complex lipids could lead to the destabilization of myelin sheath and eventually to demyelination . 45. MS features CNS inflammation, immune-mediated demyelination and neurodegeneration, and may represent an emerging class of epigenetic disorders. 46. All these four types of demyelination are non-inflammatory and different to MS even if some leukoencephalopathies can produce similar lesions 47. Mice that lose MYRF during adulthood present with a severe demyelination similar to that seen in animal models of multiple sclerosis. 48. Currently, it is possible to detect lesions before they present demyelination , and they are called pre-active lesions. 49. TNF? itself induces demyelination of the oliodendroglial via TNF receptor 1, while chronic inflammation has been linked to demyelination of neurons. 50. TNF? itself induces demyelination of the oliodendroglial via TNF receptor 1, while chronic inflammation has been linked to demyelination of neurons.
