41. For instance, friendly Saccharomyces boulardii has an enzyme which can degrade the toxins produced by the harmful Clostridium difficile . 42. "Pour dire la verite, l'Espagne sera le test le plus difficile  jusqu'a present. 43. Outbreaks of C . difficile  have killed almost 90 patients at several hospitals in both Montreal and Calgary, Alberta. 44. In 2007, there was an outbreak of " Clostridium difficile  " at hospital which killed 17 people. 45. Studies indicate that a toxin produced by Clostridium difficile  is a primary cause of " antibiotic-associated colitis ". 46. Noam's first release, " Difficile  de Choisir ", went straight to the top of the charts. 47. The copper alloys significantly reduced the viability of both " C . difficile  " spores and vegetative cells. 48. "C . difficile  " colitis is most strongly associated with fluoroquinolones, cephalosporins, carbapenems, and clindamycin. 49. PPIs may be associated with a greater risk of hip fractures and " Clostridium difficile  "-associated diarrhea. 50. Should the patient subsequently develop " C . difficile  " infection the sample is extracted with saline and filtered.