41. For instance, friendly Saccharomyces boulardii has an enzyme which can degrade the toxins produced by the harmful Clostridium difficile . 42. "Pour dire la verite, l'Espagne sera le test le plus difficile jusqu'a present. 43. Outbreaks of C . difficile have killed almost 90 patients at several hospitals in both Montreal and Calgary, Alberta. 44. In 2007, there was an outbreak of " Clostridium difficile " at hospital which killed 17 people. 45. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of " antibiotic-associated colitis ". 46. Noam's first release, " Difficile de Choisir ", went straight to the top of the charts. 47. The copper alloys significantly reduced the viability of both " C . difficile " spores and vegetative cells. 48. "C . difficile " colitis is most strongly associated with fluoroquinolones, cephalosporins, carbapenems, and clindamycin. 49. PPIs may be associated with a greater risk of hip fractures and " Clostridium difficile "-associated diarrhea. 50. Should the patient subsequently develop " C . difficile " infection the sample is extracted with saline and filtered.