As with other regions, tubule cells in the distal convoluted tubule possess the Na + / K +-ATPase ), which uses energy from ATP to transfer three sodium ions out from the basolateral surface ( toward blood vessels ) while simultaneously transferring two potassium ions in.
42.
When released, ADH binds to V2 G-protein coupled receptors within the distal convoluted tubules, increasing cyclic AMP, which couples with protein kinase A, stimulating translocation of the aquaporin 2 channel stored in the cytoplasm of the distal convoluted tubules and collecting ducts into the apical membrane.
43.
When released, ADH binds to V2 G-protein coupled receptors within the distal convoluted tubules, increasing cyclic AMP, which couples with protein kinase A, stimulating translocation of the aquaporin 2 channel stored in the cytoplasm of the distal convoluted tubules and collecting ducts into the apical membrane.
44.
This dilution, otherwise described as a reduction in plasma osmolality, is detected by osmoreceptors in the hypothalamus of the brain and these then switch off the release of ADH . The decreasing concentration of ADH effectively inhibits the aquaporins in the collecting ducts and distal convoluted tubules in the nephrons of the kidney.
45.
The gene Claudin-16 was cloned by Simon " et al . " ( 1999 ), The expression pattern of the gene was determined by RT-PCR, and was shown to be very tightly confined to a continuous region of the kidney tubule running from the medullary thick descending limb to the distal convoluted tubule . strengthening the links between the gene and the uptake of Mg 2 +.
46.
N a +-C l " cotransporter "', abbreviated as NCC or NCCT, or as the "'t hiazide-s ensitive Na +-Cl " c otransporter "'or TSC for short ) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron.
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